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Dr. Sebastian Wachsmann-Hogiu

Dr. Sebastian Wachsmann-HogiuDr. Sebastian Wachsmann-Hogiu is an Associate Professor in the Department of Pathology & Laboratory Medicine at the University of California, Davis.  In addition, he holds a joint appointment as the Facilities Director of the National Science Foundation Center for Biophotonics Science & Technology at the UC Davis Medical Center in Sacramento, CA.  

His research interests include time-resolved Raman spectroscopy/imaging, nonlinear microscopy, and SERS-based biosensors.

Dr. Wachsmann-Hogiu holds a major in Biophysics from Bucharest University in Romania.  In 2000 he received his PhD in Experimental Physics from Humboldt University/Max-Born-Institute, Berlin, where he used time-resolved Raman/CARS spectroscopy to investigate elementary chemical reactions.  After two-years of a postdoctoral appointment in the Chemistry Department at Carnegie-Mellon University, where he performed Stark spectroscopy on conductive polymers and biological materials, he moved to Cedars-Sinai Medical Center as a Research Scientist I. 

In March 2005, he became faculty (Assistant Professor) within the Surgery Department as well as Director of the Advanced Optical Imaging Laboratory within the Minimally Invasive Surgical Technologies Institute.  It was here that Dr. Wachsmann-Hogiu became interested in translating novel optical technologies into viable tools for biomedical applications. 

Research projects in Dr. Wachsmann-Hogiu’s laboratory include technology development and applications to the biomedical field and renewable energies:
        - Time-resolved Raman/fluorescence spectroscopy and imaging
        - Plasmonics and Surface Enhanced Raman Spectroscopy (SERS)
        - Biosensors and assays
        - Fiber-based Raman/fluorescence endoscopes
        - Point of care diagnosis
        - Nonlinear microscopy
        - High-resolution microscopy
        - Light conversion and energy storage

His research work has been supported by several agencies including NSF and NIH.

To read more about Dr. Wachsmann-Hogiu and his current research projects, please click on 
Current group members include: Cynthia Pagba (postdoctoral researcher), Zack Smith (postdoctoral researcher), and Florian Knorr (graduate student). 

Abbreviated List of Publications: 
1.    Wachsmann-Hogiu S. and Farkas D. L., “Nonlinear multi-spectral optical imaging microscopy: concepts, instrumentation and applications”, Chapter 19 in the book “Handbook of Biological Nonlinear Optical Microscopy” in press, Oxford University Press, Editors: B. Masters and P. So.
2.    Ljubimova J. Y., Fujita M., Khazenzon N. M., Lee B.-S., Wachsmann-Hogiu S., Farkas D. L., Black K. L., Holler E., “Nanoconjugate based on polymalic acid for tumor targeting”, Chemico-Biological Interactions., Vol. 171, Issue2, 2008, pp. 195-203.
3.    I. W. Schie, T. Weeks, G. P. McNerney, S. Fore, J. K. Sampson, S. Wachsmann-Hogiu, J. C. Rutledge, and T. Huser, “Simultaneous forward and epi-CARS microscopy with a single detector by time-correlated single photon counting”, Optics Express, Vol 16, No. 3, Feb. 2008, pp. 2168-2175.
4.    Rativa D., Gomes A. S., Wachsmann-Hogiu S., Farkas D. L., and DeAraujo R. E., “Nonlinear excitation of tryptophan emission enhanced by silver nanoparticles”, Journal of Fluorescence, 2008, April 1st, Vol 18. No. 6, Nov. 2008, pp. 1151-1155.
5.    Chan J., Fore S., Wachsmann-Hogiu S., Huser T., “ Raman spectroscopy and microscopy of individual cells and cellular components”, Laser&Photonics Reviews, Vol. 2, No. 5, 2008, pp. 325-349 (with cover). 
6.    K. Burton, J. Jeong, S. Wachsmann-Hogiu, D. L. Farkas, “Spectral Optical Imaging in Biology and Medicine” Chapter in “Biomedical Optical Imaging”, published by Oxford University Press, Editors: J. Fujimoto and D. L. Farkas, December 2008, Chapter 2.
7.    Argov N., Wachsmann-Hogiu S., Freeman S., Huser T., Lebrilla C., German B. J., “Size-dependent lipid content in human milk fat globules”, J. Agric. Food Chem., Vol. 56, No. 16, 2008, pp. 7446-7450. 
8.    H. Cho, B. R. Baker, S. Wachsmann-Hogiu, C. Pagba, T. A. Laurence, S. M. Lane, L. P. Lee, and J. B.-H. Tok, “Aptamer-based SERRS Sensor for Thrombin Detection”, 2008, Nanoletters, Vol. 8, No. 12, 2008, pp. 4386-4390.
9.    S. Wachsmann-Hogiu, T. Weeks, T. Huser, “Chemical analysis in vivo and in vitro Raman spectroscopy – from single cells to humans”, Current Opinions in Biotechnology, 2009, March 4-th ahead of print.
10.    D. Talavera, D.C. Dafoe, T. Ng, S. Wachsmann-Hogiu, C. Castillo-Henkel, D. L. Farkas, “Enhancement of embryonic stem cell differentiation promoted by avian chorioallantoic membranes”, Tissue Engineering, online ahead of print, 2009.
11.    D. L. Thompson, F. Pearson, C. Thomas, R. Rao, D. Matthews, J. S. Albala, S. Wachsmann-Hogiu, M. A. Coleman, “An adaptable, portable microarray reader for biodetection”, Sensors, Vol. 9, No. 4, 2009, pp. 2524-2537.
12.    T. Weeks, S. Wachsmann-Hogiu, T. Huser, “Doubly-Resonant four-wave mixing (DR-FWM) microscopy with two Raman resonances”, Opt. Express, Vol. 17, Issue 19, 2009, pp. 17044-17051. 
13.    C. V. Pagba, S. M. Lane, S. Wachsmann-Hogiu, “Raman and SERS studies of the 15-mer DNA Thrombin Binding Aptamer”, Journal of Raman Spectroscopy, online ahead of print, 2009.
14.    Moritz T.J., Brunberg J.A, Krol D.M., Wachsmann-Hogiu S., Lane S.M., Chan J.W., Characterization of FXTAS related isolated intranuclear protein inclusions using laser tweezers Raman spectroscopy”, Journal of Raman Spectroscopy, online ahead of print, 2009.
15.    T. Weeks, S. Wachsmann-Hogiu, T. Huser, “Doubly-Resonant four-wave mixing (DR-FWM) microscopy with two Raman resonances”, Opt. Express, Vol. 17, Issue 19, 2009, pp. 17044-17051. 
16.    T. Weeks, I. Schie, S. Wachsmann-Hogiu, T. Huser, “ Non-degenerate coherent anti-Stokes Raman scattering (CARS) microscopy”, J. of Biophotonics, 2009, online ahead of print.

Professional affiliations:
American Physical Society
Biophysical Society
American Chemical Society

Sebastian Wachsmann-Hogiu
NSF Center for Biophotonics, Science and Technology
University of California, Davis
2700 Stockton Blvd., Suite 1400
Sacramento, CA 95817
Phone: 916-734-1774